Transient regulatory T-cell (Treg) depletion with IL-2 diphtheria toxin fusion protein enhances clearance of acute myeloid leukemia by haploidentical natural killer (NK) cells
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چکیده
Transient regulatory T-cell (Treg) depletion with IL-2 diphtheria toxin fusion protein enhances clearance of acute myeloid leukemia by haploidentical natural killer (NK) cells Veronika Bachanova, Sarah Cooley, Todd Defor, Michael R Verneris, Bin Zhang, David McKenna, Julie Curtsinger, Angela Panoskaltsis-Mortari, Dixie Lewis, Keli Hippen, Philip McGlave, Daniel Weisdorf, Bruce R Blazar, Jeffrey S Miller
منابع مشابه
Plenary Paper CLINICAL TRIALS AND OBSERVATIONS Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein
• Depletion of host regulatory T cells with IL2DT improves efficacy of haploidentical NK cell therapy for refractory acute myeloid leukemia. • Depletion of Treg and persistence of NK cells for $7 days after NK cell adoptive transfer predicts beneficial clinical responses. Haploidentical natural killer (NK) cell infusions can induce remissions in some patients with acute myeloid leukemia (AML) b...
متن کاملClearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein.
Haploidentical natural killer (NK) cell infusions can induce remissions in some patients with acute myeloid leukemia (AML) but regulatory T-cell (Treg) suppression may reduce efficacy. We treated 57 refractory AML patients with lymphodepleting cyclophosphamide and fludarabine followed by NK cell infusion and interleukin (IL)-2 administration. In 42 patients, donor NK cell expansion was detected...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein
http://bloodjournal.hematologylibrary.org/content/123/25/3855.full.html Updated information and services can be found at: (424 articles) Plenary Papers (1213 articles) Myeloid Neoplasia (5193 articles) Immunobiology (2531 articles) Free Research Articles (3892 articles) Clinical Trials and Observations Articles on similar topics can be found in the following Blood collections http://bloodj...
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Thirteen patients with acute myeloid leukemia, 5 with active disease, 2 in molecular relapse, and 6 in morphologic complete remission (CR; median age, 62 years; range, 53-73 years) received highly purified CD56(+)CD3(-) natural killer (NK) cells from haploidentical killer immunoglobulin-like receptor-ligand mismatched donors after fludarabine/cyclophosphamide immunosuppressive chemotherapy, fol...
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Denileukin diftitox (DD), a fusion protein comprising IL-2 and diphtheria toxin, was initially expected to enhance antitumor immunity by selectively eliminating regulatory T cells (Tregs) displaying the high-affinity IL-2R (a-b-g trimers). Although DD was shown to deplete some Tregs in primates, its effects on NK cells (CD16 + CD8 + NKG2A + CD3 2), which constitutively express the intermediate-...
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